![]() ![]() The website also provide links to the program background and its approaches to drug discovery, a list of available “open” targets, assay-validation protocols, testing flow schemes, and descriptions and standards for in vitro, phenotypic, and tuberculosis assays. Which is available to authorized users, includes both phenotypic and target-based assay modules, with information on the collected and curated best practices for the enablement, statistical validation, operations, and quality control of various in vitro assay formats. Note that some of the MLPCN Centers were also participants in the MLSCN. MLSCN, the 3-year pilot phase of the Molecular Libraries Initiative (MLI) MLPCN, the 6-year production phase of the Molecular Libraries Program (MLP). PubChem will continue in its current mission. The processes and standards developed and optimized for data extraction, transformation, curation, and migration during this phase of BARD will be used on a continuing basis to migrate relevant new data from PubChem and from additional data sources into BARD. In an effort to ensure the integrity, accessibility, use, and impact of this valuable data set, the MLP leadership funded an administrative supplement in 2012 to create the BioAssay Research Database (BARD) and migrate existing Molecular Libraries Screening Centers Network (MLSCN) and MLPCN PubChem data into it. Funding for this National Institutes of Health (NIH) Roadmap Molecular Libraries Program (MLP) is scheduled to end in May of 2014. Within PubChem, approximately 90% of the data on active substances, a large part of the current chemical-biology data in the public domain, have been generated by the nine centers comprising the Molecular Libraries Probe Production Centers Network (MLPCN) ( Table 1). We review the technical and organizational challenges overcome by the interdisciplinary BARD team, veterans of public- and private-sector data-integration projects, who are collaborating to describe (functional specifications), design (technical specifications), and implement this next-generation software solution. We initially focused on migrating the highest-value MLP data into BARD and bringing it up to this new standard. BARD evolves the current data standards through structured assay and result annotations that leverage BioAssay Ontology and other industry-standard ontologies, and a core hierarchy of assay definition terms and data standards defined specifically for small-molecule assay data. ![]() ![]() Its initial focus is to enable scientists to more effectively use the National Institutes of Health Roadmap Molecular Libraries Program (MLP) data generated from the 3-year pilot and 6-year production phases of the Molecular Libraries Probe Production Centers Network (MLPCN), which is currently in its final year. The BioAssay Research Database (BARD) was conceived to address these challenges and serve as a community-wide resource and intuitive web portal for public-sector chemical-biology data. These require the effective integration of chemical and biological information from diverse data sources, which presents key informatics, personnel, and organizational challenges. Recent industry–academic partnerships involve collaboration among disciplines, locations, and organizations using publicly funded “open-access” and proprietary commercial data sources. ![]()
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